Job description
Analytical Chemist
Boston, MA
$35-40/hr
The Analytical Chemist will become a member of the Mass Spectrometry team. This position involves the comprehensive development, validation, and execution of LC-MS methods spanning a wide array of modalities, including primary metabolites, small molecules, intricate peptides, and whole proteins.
Key Responsibilities of the Analytical Chemist:
- Method Development: Create and refine reliable LC-MS/MS methods to quantify and characterize small molecules, specialized metabolites, peptides, and proteins.
- Instrumentation: Operate, maintain, and troubleshoot cutting-edge mass spectrometers, particularly Thermo Orbitrap (Exploris/Lumos) and Triple Quadrupole (TSQ) systems.
- Data Processing: Leverage advanced software tools (such as TraceFinder, Compound Discoverer, Proteome Discoverer, or Skyline) to analyze complex datasets and provide meaningful insights to project teams.
- Independent Execution: Oversee multiple projects concurrently, from the design of experiments and preparation of samples to the final reporting of data, working with minimal oversight.
- Cross-Functional Collaboration: Collaborate with metabolic engineers, synthetic biologists, and automation engineers to incorporate analytical assays into high-throughput workflows.
Qualifications for the Analytical Chemist:
- Master’s degree in Analytical Chemistry, Biochemistry, or a close relevant discipline; alternatively, a Bachelor’s degree accompanied by over 3 years of pertinent industrial experience.
- Practical experience with high-resolution accurate mass (HRAM) and MRM/SRM protocols.
- Proficient in various chromatography techniques including RPLC, HILIC, and Ion Exchange.
- Acquainted with sample preparation methods for biological matrices (including SPE, SLE, and protein precipitation).
- Strong problem-solving skills to address hardware complications and analyze challenging biological data.
- Exceptional written and verbal communication abilities, capable of conveying complex analytical results to non-specialist audiences.
